Naloxone

 

Naloxone	Situation	Concern	References
Pregnancy	Category C		[1] [2]
Contraindicated	Allergy
controversial	Seizure	Naloxone alone reduced the number and duration of seizures but increased the number of mild seizures	[3 [4][5][6]
controversial	Alcohol intoxicated	Lacks effectiveness in ethylic coma	[7]
Precautions	Bronchospasm	Hypoxia risk	[8]
Precautions	COPD	Hypoxia risk	[2]
Precautions	Respiratory failure/ distress	Hypoxia risk	[2]
Precautions	Lung edema, non-cardiogenic	Hypoxia risk	[2]
Adverse effect	BPH	Acute urinary retention. (AUR)	[9]
Adverse effect	Acute abdomen, pancreatitis	Induced.	[10]
Treatment	Acute abdomen, IBD	Efective and safe, and could be considered for the treatment of therapy refractory IBD patients	[11]
Precautions	Liver, renal impaired function	Hepatitis	[2]
Contraindicated	hypothyroidism	Increment oxygen consumption, but not ventilation.	[12]

 

References

[1] Goldfrank’s p.541, 11th ed.

[2] https://www.ncbi.nlm.nih.gov/books/NBK534811/

[3] https://pubmed.ncbi.nlm.nih.gov/32133101/

[4] https://pubmed.ncbi.nlm.nih.gov/30676832/

[5] https://pubmed.ncbi.nlm.nih.gov/34051813/

[6] https://pubmed.ncbi.nlm.nih.gov/15167188/

[7] https://pubmed.ncbi.nlm.nih.gov/8115696/

[8] https://pubmed.ncbi.nlm.nih.gov/23380114/

[9] https://pubmed.ncbi.nlm.nih.gov/31975924/

[10] https://pubmed.ncbi.nlm.nih.gov/27922226/

[11] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845217/

[12] https://pubmed.ncbi.nlm.nih.gov/7800724/

Edited by Yu-Jang Su    Aug 13, 2022