MMH ED Poison Center: Current 10 articles related to New Psychoactive Substance

2023年1月4日星期三

Current 10 articles related to New Psychoactive Substance

Country	Journal	Date	Important information	References
Spain	Anal Methods	2023 Jan 3	Using Membrane-assisted solvent extraction followed by liquid chromatography-tandem mass spectrometry for urine testing	[1]
Canada	Nicotine Tob Res.	2023 Jan 2	Compassion clubs are a model for the distribution of psychoactive substances that are focused on harm reduction and social support rather than profit.	[2]
Australia	Front Psychiatry.	2022 Dec 15	Synthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances that have been associated with multiple instances and types of toxicity. Some "off-targets" could possibly contribute to the SCRA toxidrome, particularly at high concentrations, CB1-mediated cellular dysfunction provides support for hypotheses concerning on-target, rather than off-target, toxicity.	[3]
UK	Drug Test Anal.	2022 Dec 29.	Higher drug levels were detected in leg hair for cannabinol, THC, methadone, and EtG and in beard hair for THC, THC-COOH, and 6-acetylmorphine. In contrast, significantly lower levels were detected in axilla hair for cannabinol, THC and for EDDP, but median levels of mephedrone and DHEA were higher.	[4]
France	Rev Epidemiol Sante Publique.	2022 Dec 24	Drug consumption rooms (DCR) are devices that target people who inject drugs (PWID) exposed to high sanitary or social risks, i.e. people living in precarious conditions, who have to inject in public spaces, in deleterious sanitary environments and with rapid gestures in order not to be seen. These analyzes highlight that the people who most want to attend a DCR are aware of the harms associated with their practices and show a desire to seek protection from street-based drug scenes.	[5]
Taiwan	J Forensic Leg Med.	2022 Dec 22	NPS users were 5.7 years younger than non-NPS drug users (37 vs. 42.7 years, p = 0.022). NPS users had a 2.6-fold higher rate of suicide and a 2.9-fold greater possibility of violence than non-NPS drug users. Moreover, NPS users experienced a 4.3-fold greater feeling of palpitation (p = 0.024) and had an 8.1-fold higher chance of presenting facial flush (p = 0.032) than non-NPS drug users.	[6]
Czech Republic	Pharmaceuticals (Basel).	2022 Nov 30	Find a synthetic pathway for a novel synthetic cathinone, namely 4-isobutylmethcathinone, and describe its spectroscopic properties and biological activity in vitro. Higher cytotoxicity in comparison with other synthetic cathinones. In the receptor binding studies, a significant difference in the agonistic effect on dopamine and adrenergic receptors of individual enantiomers was observed. The lack of binding affinity towards the serotonin receptors then relates 4-isobutylmethcathinone to the family of monoamine drugs, such as 3,4-methylenedioxymathamphetamine (ecstasy, MDMA).	[7]
Germany	Metabolites.	2022 Dec 2	In Vitro and In Vivo Toxicometabolomics of the Synthetic Cathinone PCYP Studied by Means of LC-HRMS/MS	[8]
France	Int J Mol Sci.	2022 Dec 8	Arylcyclohexylamine (ACH) compounds such as ketamine, phencyclidine and eticyclidine derivatives are rapidly increasing use and the absence of detailed toxicity data. First used mainly for their pharmacological properties in anesthesia, their recreational use is increasing. ACH derivatives have an antagonistic activity against the N-methyl-D-aspartate receptor, which leads to dissociative effects (dissociation of body and mind). Synthetic ketamine derivatives produced in Asia are now arriving in Europe, where most are not listed as narcotics and are, thus, legal. These structural derivatives have pharmacokinetic and pharmacodynamic properties that are sometimes very different from ketamine.	[9]
Sweden. Netherlands. USA. UK.	Basic Clin Pharmacol Toxicol.	2022 Dec 21	4'Cl-cumyl-PINACA (SGT-157), 4'F-cumyl-5F-PINACA (4F-cumyl-5F-PINACA, SGT-65) and 4'F-cumyl-5F-PICA (4F-cumyl-5F-PICA, SGT-64) are a series of new halogenated cumyl synthetic cannabinoid receptor agonists (SCRAs). Many metabolites retained halogen groups at the cumyl moieties which, in various combinations, may be suitable as analytical biomarkers.	[10]