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Country
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Journal
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Date
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Important information
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References
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Spain
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Anal Methods
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2023 Jan 3
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Using Membrane-assisted solvent
extraction followed by liquid chromatography-tandem mass spectrometry for
urine testing
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[1]
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Canada
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Nicotine Tob Res.
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2023 Jan 2
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Compassion clubs are a model for the
distribution of psychoactive substances that are focused on harm reduction
and social support rather than profit.
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[2]
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Australia
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Front Psychiatry.
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2022 Dec 15
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Synthetic cannabinoid receptor agonists
(SCRAs) are a diverse class of new psychoactive substances that have been
associated with multiple instances and types of toxicity. Some
"off-targets" could possibly contribute to the SCRA toxidrome,
particularly at high concentrations, CB1-mediated cellular dysfunction
provides support for hypotheses concerning on-target, rather than off-target,
toxicity.
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[3]
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UK
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Drug Test Anal.
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2022 Dec 29.
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Higher drug levels were detected in leg
hair for cannabinol, THC, methadone, and EtG and in beard hair for THC,
THC-COOH, and 6-acetylmorphine.
In contrast, significantly lower levels
were detected in axilla hair for cannabinol, THC and for EDDP, but median
levels of mephedrone and DHEA were higher.
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[4]
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France
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Rev Epidemiol Sante Publique.
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2022 Dec 24
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Drug consumption rooms (DCR) are devices
that target people who inject drugs (PWID) exposed to high sanitary or social
risks, i.e. people living in precarious conditions, who have to inject in
public spaces, in deleterious sanitary environments and with rapid gestures
in order not to be seen.
These analyzes highlight that the people
who most want to attend a DCR are aware of the harms associated with their
practices and show a desire to seek protection from street-based drug scenes.
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[5]
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Taiwan
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J Forensic Leg Med.
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2022 Dec 22
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NPS users were 5.7 years younger than non-NPS
drug users (37 vs. 42.7 years, p = 0.022).
NPS users had a 2.6-fold higher rate of
suicide and a 2.9-fold greater possibility of violence than non-NPS drug
users. Moreover, NPS users experienced a 4.3-fold greater feeling of
palpitation (p = 0.024) and had an 8.1-fold higher chance of presenting facial
flush (p = 0.032) than non-NPS drug users.
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[6]
|
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Czech Republic
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Pharmaceuticals (Basel).
|
2022 Nov 30
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Find a synthetic pathway for a novel
synthetic cathinone, namely 4-isobutylmethcathinone, and describe its
spectroscopic properties and biological activity in vitro.
Higher cytotoxicity in comparison with
other synthetic cathinones. In the receptor binding studies, a significant
difference in the agonistic effect on dopamine and adrenergic receptors of
individual enantiomers was observed.
The lack of binding affinity towards the
serotonin receptors then relates 4-isobutylmethcathinone to the family of
monoamine drugs, such as 3,4-methylenedioxymathamphetamine (ecstasy, MDMA).
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[7]
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Germany
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Metabolites.
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2022 Dec 2
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In Vitro and In Vivo Toxicometabolomics
of the Synthetic Cathinone PCYP Studied by Means of LC-HRMS/MS
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[8]
|
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France
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Int J Mol Sci.
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2022 Dec 8
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Arylcyclohexylamine (ACH) compounds such
as ketamine, phencyclidine and eticyclidine derivatives are rapidly
increasing use and the absence of detailed toxicity data.
First used mainly for their pharmacological
properties in anesthesia, their recreational use is increasing.
ACH derivatives have an antagonistic
activity against the N-methyl-D-aspartate receptor, which leads to
dissociative effects (dissociation of body and mind).
Synthetic ketamine derivatives produced
in Asia are now arriving in Europe, where most are not listed as narcotics
and are, thus, legal.
These structural derivatives have
pharmacokinetic and pharmacodynamic properties that are sometimes very
different from ketamine.
|
[9]
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Sweden. Netherlands. USA. UK.
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Basic Clin Pharmacol Toxicol.
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2022 Dec 21
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4'Cl-cumyl-PINACA (SGT-157),
4'F-cumyl-5F-PINACA (4F-cumyl-5F-PINACA, SGT-65) and 4'F-cumyl-5F-PICA
(4F-cumyl-5F-PICA, SGT-64) are a series of new halogenated cumyl synthetic
cannabinoid receptor agonists (SCRAs).
Many metabolites retained halogen groups
at the cumyl moieties which, in various combinations, may be suitable as
analytical biomarkers.
|
[10]
|
[1] https://pubmed.ncbi.nlm.nih.gov/36594640/
[2] https://pubmed.ncbi.nlm.nih.gov/36591922/
[3] https://pubmed.ncbi.nlm.nih.gov/36590635/
[4] https://pubmed.ncbi.nlm.nih.gov/36581323/
[5] https://pubmed.ncbi.nlm.nih.gov/36571957/
[6] https://pubmed.ncbi.nlm.nih.gov/36571928/
[7] https://pubmed.ncbi.nlm.nih.gov/36558946/
[8] https://pubmed.ncbi.nlm.nih.gov/36557246/
[9] https://pubmed.ncbi.nlm.nih.gov/36555217/
[10] https://pubmed.ncbi.nlm.nih.gov/36544361/
edited by Yu-Jang Su Jan 4, 2023
