Lantana camara poisoning

 

Substance: Lantana camara, News:  https://www.youtube.com/watch?v=LNrUYoL3N-E

 

Common Name: Common Lantana, 馬纓丹、五色梅、紅黃花、臭草[1]

 

Involving System      

- Gastrointestinal (GI): Acute cases develop hemorrhagic diarrhea. Chronic poisoning results in constipation. [2]

- Hepatic (Liver): Lantana contains lantadene-type toxins (such as lantadene A and B), which can cause hepatocellular injury and may lead to cholestasis [3]. Animal cases: In livestock such as cattle and horses, poisoning commonly results in liver damage and photosensitivity reactions [4]; such effects are rare in humans.

- Renal (less common) [5]

 

Presentation      

Nausea (0.3%), vomiting (4.7%), diarrhea (0.94%), abdominal pain (1.2%) [6]

Abnormal liver function (jaundice, elevated AST/ALT) [7]

Drowsiness (0.5%), weakness [6]

Rare: renal failure, arrhythmias, photosensitivity reactions (more common in animals) [5], [7]

 

Antidote / Treatment     

- （No specific antidote）

-  （Supportive care）activated charcoal [8].

- Intravenous fluids, IVF、correct electrolyte imbalance. [8]

- Liver injury： Hospitalize and monitor the liver enzymes and function.

 

Disposition 

- mild： treatment and observation, discharged when improvement was achieved.

- severe: persisted liver enzymes elevated, or uneasy symptoms:  0.3% hospitalized [6], especially the children and elderly.

 

References 

[1]. https://www.agriharvest.tw/archives/16922

[2]. https://poisonousplants.cvmbs.colostate.edu/plant/64

[3]. https://pubmed.ncbi.nlm.nih.gov/431982/

[4]. https://pubmed.ncbi.nlm.nih.gov/12583691/

[5]. https://pubmed.ncbi.nlm.nih.gov/16031191/

[6]. https://pubmed.ncbi.nlm.nih.gov/21041281/

[7]. https://pubmed.ncbi.nlm.nih.gov/37054993/

[8]. https://pubmed.ncbi.nlm.nih.gov/6512165/

 

Edited by Yu-Jang Su  March 17, 2025 

 

 

 

 

Poisoning / Intoxicated Related Jaundice

 

Year	Country	Substance	Content	Reference
2020	Pakistan	Paracetamol	Presented with pain in the abdomen, vomiting, and jaundice	https://pubmed.ncbi.nlm.nih.gov/32703356/
2019	Romania	Mushroom poisoning	ALF, acute liver failure	https://pubmed.ncbi.nlm.nih.gov/35154529/
2021	Portugal	Chronic Copper Sulfate	Dysphagia to solids and liquids, anemia, acute kidney injury, liver cytolysis, and hypocalcemia.	https://pubmed.ncbi.nlm.nih.gov/33768078/
2014	France	Naphthalene, 萘	Delirium, fever and jaundice, three days after ritual ingestion of naphthalene	https://pubmed.ncbi.nlm.nih.gov/24909442/
2015	Sweden	Amanita phalloides	Gastrointestinal disorders followed by jaundice, seizures, and coma, culminating in death	https://pubmed.ncbi.nlm.nih.gov/26375431/
2008	South Korea	Chloroform and dichloromethane	Abnormal liver enzymes were noted on postingestion day 2, and jaundice occurred on postingestion day 3	https://pubmed.ncbi.nlm.nih.gov/19091298/
2005	Mexico	Arsenic	Alterations of consciousness, from confusion until delirium, crash, hematuria, jaundice and renal insufficiency.	https://pubmed.ncbi.nlm.nih.gov/15998481/
2004	Poland	Acetaminophen	Liver injury (progressive encephalopathy and jaundice, decreased prothrombin activity) developed	https://pubmed.ncbi.nlm.nih.gov/15521608/
2002	Germany	MDMA	nausea, vomiting, abdominal pain and jaundice	https://pubmed.ncbi.nlm.nih.gov/12297982/
1997	Germany	Methylenedianiline, 工業製造的化學物質，並不會自然產生，也稱為 MDA。它也被用來製造塗層材料、膠水、 纖維、染料和橡膠。 會存在空氣中的微小粒子。	Acute jaundice developed within 2 days after ingestion	https://pubmed.ncbi.nlm.nih.gov/9022650/
1985	Germany	Vitamin A	prehepatic and hepatic icterus and hypersplenism with hemolytic anemia.	https://pubmed.ncbi.nlm.nih.gov/3992236/
1989	France	Geromitra esculenta, 鹿花菌 又名鹿花蕈或河豚菌	vomiting and diarrhoea, and, afterwhile, by jaundice, convulsions and coma.	https://pubmed.ncbi.nlm.nih.gov/2681713/
1983	Australia	Phenylbutazone (NSAIDS)	coma, convulsions, diarrhoea, and of cholestatic jaundice which evolved over the succeeding 10 days.	https://pubmed.ncbi.nlm.nih.gov/6843432/

(Excluding experimental and animal studies)

 

Edited by Yu-Jang Su  Nov 29, 2022