Substance
- Paraquat.
Common name or Trade name
- 巴拉刈. 速草淨, 全草滅, 草蕪松 [1]
Involving system
- Gastrointestinal – oral, transient
liver toxicity, jaundice. [1]
- lung:
pulmonary fibrosis [1]
- kidney: ATN,
AKI [1]
- heart: hypotension,
myocarditis, arrhythmia. [1]
- AMS- mental
change. Seizure. Coma. [1]
Presentation
- Nausea, vomiting. [1]
- Diarrhea [1]
- Dyspnea [1]
-
Pneumoperitoneum,
pneumomediastinum [2].
- Seizure [1]
- jaundice [1]
- Coma [1]
- Asystole. [1]
Antidote and
Treatment
- Decontamination: remove clothes,
washing [1].
- NG irrigation within 1 hour [1].
- Fuller earth, 100—150 gm. Child: 2
gm/kg BW. Activated charcoal 25—100gm, child 25—50 gm [1].
- Hemoperfusion within 2—4 hours [1].
- Hemodialysis if renal failure [1].
- No antidote.
Disposition
- MICU in confirmed poisoning cases with
hemodynamic unstable.
- 25% to 44% of mortality rate in
pregnant women [3].
REFERENCES
1. 急診醫學會AILS三版P.85—94.
2. James N, Bakshi R, Rudresh SS, Kaushik
K, Ghumaan KS, Pannu AK. Pneumoperitoneum from pneumomediastinum in paraquat
poisoning. Trop Doct. 2020 Sep 30:49475520960872. doi:
10.1177/0049475520960872. Epub ahead of print. PMID: 32998627.
3. Trakulsrichai S, Paisanrodjanarat B,
Sriapha C, Tongpoo A, Udomsubpayakul U, Wananukul W. Clinical outcome of
paraquat poisoning during pregnancy. Clin Toxicol (Phila). 2019
Aug;57(8):712-717. doi: 10.1080/15563650.2018.1549328. Epub 2019 Jan 28. PMID:
30689470.
edited by Yu-Jang Su Feb 27, 2021.
