SUBSTANCE
異氰酸酯 (Isocyanate)
Component of organic chemistry, making them
perceived as compounds with high potential for use in both the laboratory and
industry. Such as 膠黏劑、PU樹脂、塗料、密封劑。
以MDI、TDI和多元醇預聚的產品系列。
Application: 汽車座椅方向盤等周邊、運動器材、 家俱、寢具、塗料、凝膠、滾輪、刮刀、密封件、防水材、PU跑道、再生海綿膠、人造草坪膠、軟包裝腹膜膠等用途
[1]。
Common name / Trade name
異氰酸酯
Exposure to methyl isocyanate: via route of
inhalation or dermal absorption. [2]
Involving SYSTEM
Animal
report: Imbalance of both the brain and plasma amino acids, suggesting
neurotoxic and systemic effects [3].
Rat study
report: Oncogenicity - Pulmonary adenomas were found in 6 males and 2 females,
and pulmonary adenocarcinoma in one male in the high dose group. [4]
Presentation
Toxicity might develop over 1 to 4 hours
after exposure. [2]
Toxic effect, consequently causing an
inflammatory infiltrate in the
bronchial wall (Lemiere et al., 1996),
goblet cell hyperplasia, subepithelial fibrosis
(Pons et al., 1999),
mucus plugs (Bucher et al., 1987),
and, consequently, allergic asthma. [1]
cough, dyspnea, chest pain, lacrimation,
eyelid edema, and unconsciousness. [2]
Antidote / Treatment
There is no antidote for methyl
isocyanate.
Treatment consists of removal of the victim
from the contaminated area and support of respiratory and cardiovascular
functions.
Disposition
At least observation 6 hours, in some
severe case, signs and symptoms of methyl isocyanate might progress over the
next 24 to 72 hours to include acute lung injury, cardiac arrest, and death [2].
REFERENCES
1. https://pubmed.ncbi.nlm.nih.gov/38761928/
and https://www.sciencedirect.com/science/article/abs/pii/S0048969724033977?via%3Dihub
2 CDC emergency
preparedness and response.
3: https://pubmed.ncbi.nlm.nih.gov/8956091/
4. Toxicology:
Isocyanates Profile. U.S. Environmental Protection Agency.
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