Poly-ether siloxane Mis-swallowing

 

速展王 (離子型黏著劑)

 

SUBSTANCE: Polyetheretherketone, PEEK; poly-ether siloxane.

cyclic siloxanes D4 (tetramethylcyclotetrasiloxane) and

D5 (decamethylcyclopentasiloxane) and The short-linear HMDS (hexamethyldisiloxane)

 

General information: Seek medical advice.

 

If breathing is irregular or stopped, administer artificial respiration.

Inhalation: Move to fresh air.

 

Skin Contact: Wash off immediately with soap and plenty of water.

 

Wash off immediately with plenty of water for at least 15 minutes.

Eye contact: Rinse immediately with plenty of water for at least 15 minutes. Rinse

immediately with plenty of water, also under the eyelids, for at least

15 minutes. Remove contact lenses.

 

Ingestion: Prevent aspiration of vomit. Turn victim's head to the side.

Never give anything by mouth to an unconscious person. If swallowed, seek

medical advice immediately and show this container or label.

 

Personal Protection for First aid Responders: Use personal protective equipment., Wear self-contained breathing apparatus for firefighting if necessary.

 

Most important symptoms/effects, acute and delayed

Symptoms: Up to now no symptoms are known. Hazards: No data available.

Indication of immediate medical attention and special treatment needed

Treatment: Treat symptomatically

 

Toxicokinetic: D4 is eliminated via the lungs and metabolised D4 via urine and faeces

 

Acute toxicity

In general the acute toxicity of siloxanes is considered low. LD50 following oral

administration of D4 in rats is reported to be more than 4,500 mg/kg and

more that 5,000 mg/kg for HMDS. LC50 in rats exposed to D4 was >12.17

mg/l and >48 mg/l when exposed to HMDS (European Commission 2000).

 

LD50 following dermal application of D4 was >2400 mg/kg bw. Several studies with dermal application of HMDS have shown greater LD50 values, but

mortality was observed at 10000 mg/kg bw.

 

Toxic effects at 10000 mg/kg included gross pathological findings (lung, kidney, bladder, heart), while clinical findings (altered activity, ataxia, gasping and eschar formation) occurred in small numbers of rabbits.

 

Investigation of subacute oral toxicity in rats administered between 25 and

1600 mg/kg per gavage over two week with five applications per week caused

increased relative liver weights in female animals at 100 mg/kg and male animals at 400 mg/kg. Absolute liver weight was also increased in female rats at

400 mg/kg. Decreased body weight was seen at the highest concentration in

both male and female animals (BAuA 2001).

 

 

References:

 

https://www.palmerholland.com/Assets/User/Documents/Product/49053/8825/MITM11654.pdf

 

https://www2.mst.dk/udgiv/publications/2005/87-7614-756-8/pdf/87-7614-757-6.pdf

Edited by Yu-Jang Su  Oct 19, 2023.